Aloin attenuates NMDA receptor by modulating calcium response on substantia gelatinosa neurons of the trigeminal subnucleus caudalis in mice
Abstract
influx but occurred independently of voltage-gated sodium channels and action potential generation. Calcium imaging revealed that aloin reduced NMDA-induced intracellular calcium influx, supporting its role in mitigating NMDA-mediated excitotoxicity. Furthermore, aloin significantly suppressed the spontaneous firing activity of SG neurons, suggesting its broader regulatory effects on neuronal excitability. Our findings demonstrate that aloin attenuates NMDA receptor-induced excitatory signaling by regulating calcium response. This specificity highlights aloin's potential as a therapeutic candidate for conditions involving glutamate excitotoxicity and orofacial pain regulation.
Fields of Study & Subjects
Phytochemistry and biological activity of medicinal plants
Ginseng Biological Effects and Applications
Natural Compound Pharmacology Studies
Publication details
- Journal / source
- Korean Journal of Physiology and Pharmacology
- Volume
- 30
- Issue
- 3
- Pages
- 231–239
- Publication date
- 7 January 2026
- Language
- EN