Cleaning Validation: Analytical Strategies and Practical Implementation Using Chromatographic Methods

American Journal of Analytical Chemistry 2026 Open access

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Authors: Sai Krishna Bompelliwar, Kishore Raju Vatsavai, Jayaram Kamma, Anil Kumar Ramgiri, Ravi Teja Meduri, Kishore Kumar Hotha
DOI: 10.4236/ajac.2026.173006
Cited by: 1
References: 3

Abstract

The cleaning validation is the most important step. Cleaning validation is a crucial aspect of pharmaceutical manufacturing to ensure that residues from previous batches do not contaminate subsequent products. This review explores the principles, regulatory requirements, analytical techniques, validation parameters, challenges, and future trends associated with cleaning validation. The focus is on ensuring compliance with Good Manufacturing Practices (GMP) while maintaining product safety and efficacy. This review paper provides a comprehensive review of analytical method cleaning validation procedures.

Fields of Study & Subjects

Analytical Methods in Pharmaceuticals Analytical Chemistry and Chromatography Pesticide Residue Analysis and Safety

Publication details

Journal / source
American Journal of Analytical Chemistry
Publisher
Scientific Research Publishing, Inc.
Volume
17
Issue
03
Pages
61–82
Publication date
1 January 2026