Dendritic Cell Therapy to Improve Cancer Outcomes. Recent Insights: A Narrative Review

Since long surgical excision of the tumors, followed by anti-cancer therapy, and irradiation were the basic tenets of management of all malignancies. Recently, Dendritic Cells (DCs) therapy has appeared on the horizon as a sparkling star in the management of cancer by way of Immunotherapy. DCs are essential cells that protect the human body through effective T cell actions against tumor antigens. All electronic databases for English language literature were searched which included Pub Med, Scopus, Web of Science, EBSCO Cumulative Index to Allied Health Literature, and Cochrane Central with key words of cancer, immunotherapy, dendritic cell vaccines. Our review scrutinizes salient features of how DCs form the basis of the adaptive natural immunity and play a central role in neutralizing cancer cells through T-cell responses against cancer antigens. Reports indicate that DCs actively limit tumor growth and are also involved in interfering with metastasis growth. This review aims to elucidate the benefits of DC therapy in various tumors critically.