Correlation between hCG Kinetics and the Effectiveness of Methotrexate in the Management of Ectopic Pregnancies

Purpose: To evaluate a therapeutic monitoring strategy for ectopic pregnancies treated with methotrexate (MTX) injection based on hCG level kinetics, in order to identify patients at low risk of treatment failure.Materials and Methods: This series of 14 cases allowed us to evaluate the success rate of therapeutic management with a single injection of methotrexate (MTX), based on the kinetics of hCG levels.The protocol stipulated that if the decrease was greater than 20% between days 1 and 4, follow-up was limited to an hCG measurement one month later.Results: Among the 14 patients treated, the overall success rate of MTX treatment was 85.71%.Conclusion: Our protocol allows us to select patients at low risk of failure of single-dose MTX treatment, and to offer them less restrictive monitoring.