Neurological, Neuropsychological, and Neuropsychiatric Assessment of Patients with Parkinson’s Disease for Subthalamic Nucleus Deep Brain Stimulation Surgery

Introduction: Subthalamic nucleus Deep brain stimulation surgery (STN-DBS) is a treatment used for patients in the fluctuating and advanced stages of PD.For this, patients must meet specific inclusion and exclusion criteria.The objectives of this work were to evaluate the current neurological, neuropsychiatric status, and cognitive status of patients with PD for STN-DBS.Methods: A complete semi-structured neurological and neuropsychiatric interview, validated neurological and neuropsychiatric scales, brain MRI, and Levodopa tests, and a complete neuropsychological battery were administered according to CAPSYT recommendations.Results: 48 patients with PD were evaluated; the mean age and schooling were 65.70 years (±8.06), years of illness 15.67 (±7.3), and 12.27 years (±4.28),respectively.Seventeen of these patients were excluded as candidates for neurosurgery.Five patients were excluded due to advanced PD and long disease duration, four patients were excluded due to atypical Parkinsonism, and three patients were excluded due to dementia of multiple domains with a subcortical profile and impairment in daily life activities.Five of these patients were diagnosed with Severe Major Depression Episodes and exhibited more than two of the following conditions: 1) High scores on the Beck Depression Scale; 2) High Okasha suicidality score; 3) High total