Congenital Factor VII Deficiency Revealed in the Neonatal Period: A Case Report at CHNEAR

Open Journal of Pediatrics 2026 Open access

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Authors: Maryame Aida Kane, Awa Kane, Ibrahima Bara Diop, Mame Awa Ndao, Sokhna Aïssatou Touré, Sadio Konate, Fatima Zahra Sahib, Amadou Sow, Aminata Mbaye, Aida Sarr, Souleye Sow, Abdou Aziz Faye
+11 more Mame Fama Niang, Diary Sow, Djibril Boiro, Indou Deme Ly, Babacar Niang, Abou Ba, Idrissa Demba Ba, Pape Moctar Faye, Amadou Lamine Fall, Saliou Diop, Ousmane Ndiaye
DOI: 10.4236/ojped.2026.161006
Cited by: 0
References: 9

Abstract

Congenital factor VII deficiency is a rare, autosomal recessive disorder with an estimated prevalence of 1 in 1,000,000. We report the case of a female newborn, born to second-degree consanguineous parents, admitted at 22 days of age for management of a subarachnoid hemorrhage. Hemostasis testing revealed a prothrombin time (PT) of 16%, with a preserved activated partial thromboplastin time (aPTT). Coagulation testing demonstrated an isolated factor VII deficiency. Through this case, we highlight the clinical, biological, and therapeutic characteristics of this anomaly during the neonatal period.

Fields of Study & Subjects

Hemophilia Treatment and Research Blood Coagulation and Thrombosis Mechanisms Platelet Disorders and Treatments

Publication details

Journal / source
Open Journal of Pediatrics
Volume
16
Issue
01
Pages
61–65
Publication date
1 January 2026