Intravascular lithotripsy in comparison to rotational atherectomy for calcified lesions: the ICARE OFDI randomised trial

EuroIntervention 2026 Open access

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Authors: Benjamin Honton, P Motreff, Jean-Sébastien Mallet, T H Hovasse, Matthieu Godin, Guilhem Malclès, Jerome Brunet, N Meneveau, Pierre Deharo, Benoit Lattuca, Erwan Bressollette, Michael Angioi
+10 more Hakim Benamer, Édouard Gerbaud, Bruno Pereira, Vincenzo Cesario, Antoine Poinas, Clémence Laperche, Antoine Sauguet, Géraud Souteyrand, Nicolas Amabile, Nicolas Combaret
DOI: 10.4244/eij-d-26-00426
Cited by: 3
References: 35

Abstract

BACKGROUND: The management of calcified coronary lesions remains challenging. Although several devices for advanced plaque modification are available, their relative efficacy is debated. AIMS: We aimed to compare intravascular lithotripsy (IVL)- and rotational atherectomy (RA)-based strategies for calcified plaque preparation during percutaneous coronary interventions (PCI). METHODS: , a one-sided alpha risk of 5%, and a power of 80%, under the assumption of no true difference between groups. The primary endpoint was the minimal stent area (MSA) following stent implantation. The target lesion failure (TLF) rate was analysed after 12 months. RESULTS: , respectively; p for non-inferiority

Fields of Study & Subjects

Coronary Interventions and Diagnostics Peripheral Artery Disease Management Cardiac Imaging and Diagnostics

Publication details

Journal / source
EuroIntervention
Publisher
Europa Digital & Publishing
Volume
22
Issue
15
Pages
e808–e819
Publication date
27 July 2026
Language
EN