Multidomain Improvement with a Device-free SONAPS Program in Primary Progressive Multiple Sclerosis: A Case Report

Rapid, multidomain functional improvement is uncommon in primary progressive multiple sclerosis (PPMS).We report the case of a 44-year-old man with long-standing PPMS who completed a 15-session, device-free somatic-neuropsychological adaptive programming system program over 90-days.Global disability, assessed using the composite disability and functional status scale, improved from 20/50 to 7/50.Lower-limb strength increased (Medical Research Council scale: left, 0→1; right, 2→4).The Babinski sign normalized on the right and attenuated on the left.Multiple physical and psychological symptoms improved across 0-10 severity scales.One routine rituximab infusion occurred during the intervention period.Clinical gains persisted at 3 and 9 months without relapse or regression, despite exposure to significant psychosocial stressors.No adverse events were observed.These findings warrant further investigation in controlled, blinded studies.