Intense FAPI Uptake of Pancreatic Tissue Can Mask the Tumor Activity of Pancreatic Cancer: The Importance of Dual-Tracer PET Imaging

Molecular Imaging and Radionuclide Therapy 2026 Open access

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Authors: Elife Akgün, Ahmet Ertuğrul Öztürk, Göksel Alçın, Mert Mahsuni Sevinc, Esra Arslan
DOI: 10.4274/mirt.galenos.2025.91069
Cited by: 0

Abstract

Fibroblast activation protein (FAPI), a type II transmembrane glycoprotein is a promising target to image epithelial originated cancers.Pancreatic cancer is characterized with [ 68 Ga]Ga-FAPI-04 and 18 F-fluorodeoxyglucose ( 18 F-FDG) uptake in varying degree.However physiologic uptake and uptake associated with acute/chronic pancreatitis makes interpretation challenging.We would like to present a case of pancreatic cancer whose tumor could not delineated from rest pancreatic tissue in [ 68 Ga]Ga-FAPI-04 positron emission tomography/computed tomography (PET/CT) images due to intense FAPI uptake in whole pancreas but more remarkable in 18 F-FDG PET/CT images.

Fields of Study & Subjects

Peptidase Inhibition and Analysis Medical Imaging Techniques and Applications Pancreatic and Hepatic Oncology Research

Publication details

Journal / source
Molecular Imaging and Radionuclide Therapy
Volume
35
Issue
1
Pages
70–72
Publication date
15 January 2026
Language
EN