Evaluation of Monocyte/HDL and Neutrophil/Lymphocyte Ratios in Patients with Hashimoto’s Thyroiditis

Aim: Systemic inflammation related to Hashimoto's thyroiditis (HT) is thought to increase oxidative stress, endothelial dysfunction, and the risk of cardiovascular diseases.In this study, we aimed to indirectly evaluate this risk increase through easily measurable and cost-effective parameters such as the neutrophil/lymphocyte ratio (NLR) and monocyte/high-density lipoprotein ratio (MHR). Materials and Methods:In this retrospective study, the laboratory data of patients aged between 18 and 80 who were diagnosed with hypothyroidism were reviewed.A total of 325 individuals who met the inclusion criteria were included in the study.Of these, 203 were diagnosed with HT and were divided into two subgroups: overt hypothyroidism (OH) and subclinical hypothyroidism (SH).These data were compared with those of 122 individuals in the healthy control group (CG). Results:The mean age of the control and patient groups was similar.In the evaluation of inflammatory parameters, no significant differences were observed in C-reactive protein and sedimentation values between OH, SH, and the healthy CG.There were no statistically significant differences in terms of NLR and MHR between OH, SH, and CG (p: 0.507, p: 0.064, respectively).Additionally, no correlation was found between autoantibodies and NLR or MHR parameters in the OH, SH, and CG groups.Conclusion: Parameters such as NLR and MHR could serve as practical tools in assessing oxidative stress, endothelial dysfunction, and cardiovascular disease risk in autoimmune and chronic inflammatory diseases like HT.However, further large-scale studies are needed to validate the clinical applicability of these parameters.