The Relationship between the rs5918 Polymorphism Serum GPIIb/IIIa Levels, and Biochemical Parameters in Pulmonary Embolism Associated with COVID-19 Infection

Aim: This study aimed to investigate the potential associations among serum levels of the glycoprotein Glycoprotein IIb/IIIa (GPIIb/IIIa) which plays a critical role in platelet function the rs5918 polymorphism in the ITGB3 gene, and biochemical parameters (platelet count, D-dimer, fibrinogen, mean platelet volume, C-reactive protein) in patients who developed pulmonary embolism (PE) due to coronavirus disease 2019 (COVID-19) infection. Materials and Methods:The study was conducted using DNA and serum samples from 80 adult patients diagnosed with COVID-19 between 2020 and 2022.Patients were divided into two groups as PE positive PE(+) and PE negative PE(-).The rs5918 polymorphism was analyzed using the TaqMan single nucleotide polymorphism genotyping method on a real-time polymerase chain reaction system.Serum GPIIb/IIIa levels were measured using the ELISA method.Demographic, hematological, and biochemical data were retrieved from patient records and analyzed statistically.Results: Platelet count (p=0.007) and D-dimer levels (p