Prognostic Factors and Survival Outcomes in Marginal Zone Lymphoma: Real-Life Experience

Objective: This study evaluates the clinical and prognostic features of patients with marginal zone lymphoma (MZL) and examines the impact of key prognostic factors including lactate dehydrogenase (LDH), β2-microglobulin, immunoglobulin M (IgM), and International Prognostic Index (IPI) score on survival outcomes. It also compares survival rates among extranodal, nodal, and splenic subtypes to reveal prognostic heterogeneity and provide real-world evidence for personalized treatment strategies in MZL management. Materials and Methods: A total of 79 patients aged ≥18 years with pathologically confirmed MZL diagnosed between 2015 and 2025 were retrospectively analyzed. Demographic characteristics, clinical findings, laboratory results, treatment modalities, and survival data were recorded. Survival outcomes were assessed using the Kaplan-Meier method with statistical significance set at p