Evaluation of Health-related Quality of Life among Patients with Chronic Viral Hepatitis and Non-alcoholic Fatty Liver Disease

Objectives: Chronic viral hepatitis may reduce quality of life (QoL).In this study, our aim was to assess the QoL of patients with chronic hepatitis B virus (HBV) infection and to compare these results with those of patients with non-alcoholic fatty liver disease (NAFLD) and chronic hepatitis C virus (HCV). Materials and Methods:A total of 299 consecutive patients with chronic HBV, 92 patients with chronic HCV, and 64 patients with NAFLD were included.Short form-36 (SF-36), the liver disease symptom index 2.0 (LDSI 2.0), and the sociodemographic data form were completed.Child-Pugh and the model for end-stage liver disease scores were also calculated.Results: Patients with chronic HCV had the worst scores on the SF-36 and the LDSI 2.0, followed by patients with HBV and NAFLD.Factors associated with QoL were, among patients with HCV, employment status, medical treatment, income level, presence of cirrhosis, and number of comorbid conditions; among patients with HBV, gender and presence of cirrhosis; and among patients with NAFLD, number of children, duration of disease, number of comorbid conditions, and body mass index.Conclusion: Chronic viral hepatitis had a negative impact on QoL.Patients with chronic HCV had the lowest QoL, followed by patients with chronic HBV and NAFLD.Keywords: Chronic HCV infection, chronic hepatitis B infection, NAFLD, quality of life ÖZ Amaç: Kronik viral hepatit, yaşam kalitesini (YK) olumsuz etkileyebilir.Bu çalışma, kronik hepatit B virüs (HBV) hastalarında YK'yi değerlendirmek ve sonuçlarını alkole bağlı olmayan yağlı karaciğer hastalığı (NAFLD) ve kronik hepatit C virüs (HCV) hastalarıyla karşılaştırmak amacıyla yapılmıştır.Gereç ve Yöntemler: Çalışmaya 299 HBV, 92 HCV ve 64 NAFLD hastası dahil edildi.Kısa form-36 (KF-36), karaciğer hastalığı semptom indeksi 2.0 (LDSI 2.0) ve sosyodemografik form kullanıldı. Sirozu olan hastalarda Child-Pugh ve model for end-stage liver disease skorları hesaplandı.Bulgular: Kronik HCV'li hastalar KF-36 ve LDSI 2.0'da en kötü puanları alırken, bunu HBV ve NAFLD'li hastalar izledi.Yaşam kalitesiyle ilişkili faktörler, HCV'de çalışma durumu, tıbbi tedavi, gelir düzeyi, siroz ve ek hastalık sayısı; HBV'de cinsiyet ve siroz; NAFLD'de çocuk sayısı, hastalık süresi, ek hastalık sayısı ve vücut kitle indeksi YK ile ilişkili bulundu.