Extraction of 17β Estradiol from Normal and Abnormal Endometrium

Routledge eBooks 2026 Book chapter

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Authors: Carlo Bulletti, Valerio Maria Jasonni, Fabio Cappuccini, Patrizia Maria Ciotti, G Fuschini, C Flamigni
DOI: 10.4324/9781003760542-19
Cited by: 0

Abstract

The transport of 17β estradiol (E2) into the normal, hyperplastic and neoplastic endometrium was studied by the use of single injection technique of ( 3 H)-E2 and 14 C-butanol (as freely diffusible reference substance) during the extracorporeal perfusion of human uterus. The differential permeability of vascular beds in normal and abnormal endometrium to E2 was evaluated. When protein-free Ringer’s solution was used, E2 was found to be freely diffusible into the normal and abnormal endometrium, while the extraction of E2 from human serum was 98 significantly higher in the hyperplastic and carcinomatous endometrium than in the proliferative one.

Fields of Study & Subjects

Estrogen and related hormone effects Endometrial and Cervical Cancer Treatments Reproductive System and Pregnancy

Publication details

Journal / source
Routledge eBooks
Pages
97–102
Publication date
30 January 2026
Language
EN
Document type
Book chapter