Estriol-Like Activity by RIA in Breast Cancer Cytosol. Relationships with Estradiol Levels and Receptor Status

Routledge eBooks 2026 Book chapter

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Authors: Massimo Gion, Ruggero Dittadi, Lorenzo Colombo, Riccardo Mione, Michele Bellenzier, Giuliano Bruscagnin
DOI: 10.4324/9781003760542-20
Cited by: 0

Abstract

Growth of breast cancer is regulated by steroid hormones when specific receptors are present. However, breast cancer can metabolize steroid hormones, this activity being more evident in receptor negative cases 1 . Among the steroids measured in breast cancer tissue fractions, 17 β -estradiol (E2) plays a major role. E2 may be trasformed into estriol 2 (E3) through 16α—hydroxylation 2 , or, through 2-hydroxylation, into 2-hydroxyestradiol, a compound which, differently from estriol 3 - 4 , lacks peripheral estrogenic activity 5 .

Fields of Study & Subjects

Estrogen and related hormone effects Breast Cancer Treatment Studies Steroid Chemistry and Biochemistry

Publication details

Journal / source
Routledge eBooks
Pages
103–108
Publication date
30 January 2026
Language
EN
Document type
Book chapter