Illuminating inflammation in parkinson’s disease: an innovative approach to the relationship between serum calprotectin and C-reactive protein

Aim: Parkinson's disease (PD) is a disorder that affects 3.7% of people over the age of 65 and encompasses several neurodegenerative changes.Calprotectin is an inflammatory response-associated protein, while C-reactive protein (CRP) serves as a marker of inflammation.The aim of this study is to investigate the inflammatory aspect of PD by comparing serum calprotectin levels and CRP/albumin ratio (CAR) between patients and healthy subjects.Materials and Methods: This study was conducted on 78 participants, including PD patients and a healthy control group.Venous blood samples were taken for molecular analysis and the levels of serum calprotectin, CRP and albumin were assessed.Results: Serum levels of CRP and CAR were significantly higher in PD patients compared to controls, while albumin levels were low.However, there was no significant difference in serum calprotectin levels between the groups.Moderate to low linear relationships were observed between CRP and CAR with disease stage.The sensitivity of CAR in PD was found to be 44.7% with a specificity of 100%.Discussion: The results of this study demonstrate that inflammatory markers (especially CRP and CAR) are elevated in PD and suggest their possible prognostic importance in the course of the disease.A negative association was found between albumin levels and disease duration, whereas no significant difference in serum calprotectin levels was found between PD patients and controls.Overall, the role of inflammation in PD and the prognostic value of calprotectin suggest the need for further research.