Effectiveness of an Integrated One Health Intervention on Schistosoma japonicum Infection in Wild Rodents — Anhui Province, China, 2022–2024

What is already known about this topic? Schistosomiasis represents a natural focal disease in which wild rodents function as critical reservoir hosts for Schistosoma japonicum transmission within specific endemic regions of China. What is added by this report? Implementation of a comprehensive 2-year One Health intervention package demonstrated a significant reduction in S. japonicum infection rates among wild rodents, declining from 69.15% to 22.09%, with intervention villages showing an 88.46% decrease in infection odds compared to control villages. What are the implications for public health practice? Integrating One Health intervention measures into schistosomiasis control programs could effectively reduce infection risk among environmental reservoir hosts and mitigate transmission risks to human populations.