A REVIEW ON THE POSSIBILITIES OF INTEGRATING AYURVEDA PRAKRITI PARIKSHAN(AYURVEDA BODY TYPE ANALYSIS) WITH ORGAN-ON-A-CHIP TECHNOLOGY FOR SHAPING THE UPCOMING PERSONALISED MEDICINE

Background: The move toward personalised medicine highlights the importance of customising drug develop-ment and treatment to individual biological differences. Variations in how people respond to drugs, both in effec-tiveness and safety, are still significant challenges in clinical and pharmaceutical research. Ayurveda, India's traditional medicine system, offers a way to profile individuals through Prakriti Parikshan(Constitutional as-sessment), which categorises people into three types—Vata, Pitta, and Kapha—each associated with specific physical and metabolic traits. Methods: This study combines the Ayurvedic classification model based on Pra-kriti with Organ-on-a-Chip (OoC) technology. The proposed method involves grouping human cell lines by Pra-kriti type and applying them to OoC systems that mimic organ-level microphysiology. This setup enables real-time modelling of drug effects tailored to each patient. Results: By simulating different metabolic and cellular responses within Prakriti-specific organ models, this integrated approach can uncover how constitution influ-ences drug responses. The combined OoC platform has the potential to improve prediction accuracy in preclini-cal testing, refine dose formulations, and reduce failures in late-stage drug development. Conclusion: Merging Prakriti Parikshan with OoC technology creates a new framework for personalised medicine, connecting tradi-tional Ayurvedic wisdom with modern microphysiology. This model may accelerate the development of cost-effective, constitution-specific drugs and enhance personalised treatment design.