International Journal of Academic Medicine and Pharmacy

Background: Ectopic pregnancy remains a major contributor to early pregnancy morbidity.Single-dose methotrexate is an established medical treatment, and early β-hCG dynamics may aid prediction of therapeutic response.The aim is to evaluate whether initial β-hCG level and day-4 β-hCG changes predict the outcome of single-dose methotrexate treatment in tubal ectopic gestation.Materials and Methods: A prospective observational study was conducted among 30 haemodynamically stable patients with tubal ectopic pregnancy managed with a single-dose methotrexate protocol in a tertiary care hospital over one year.Serum β-hCG levels were measured on days 1, 4, and 7. Treatment success was defined as resolution without additional methotrexate or surgery.Associations between β-hCG kinetics, sac size, and outcomes were analysed using chi-square tests and ANOVA, with p