Liposarcoma: Clinical Presentation and Surgical Approach. Case Report

Liposarcoma is a rare malignant soft tissue neoplasm characterized by a nonspecific clinical presentation and variable biological behavior, which may lead to diagnostic delays, particularly in uncommon anatomical locations. We report the case of a 55-year-old female patient presenting with a progressively enlarging mass in the gluteal region, with a prolonged course and minimal initial symptoms. Imaging studies suggested a soft tissue neoplasm, and the diagnosis of liposarcoma was confirmed by histopathological examination. The patient underwent wide oncologic surgical resection with negative margins, which constituted the definitive treatment. The procedure was performed without intraoperative complications, with a favorable postoperative course and adequate functional preservation. This case report highlights the importance of including liposarcoma in the differential diagnosis of progressively growing gluteal masses, as well as the fundamental role of adequate surgical resection as the cornerstone of treatment, emphasizing the need for a timely and multidisciplinary approach to optimize oncologic and functional outcomes.