Correlation between Toxoplasma gondii Infection and ABO Blood Groups and RH in Individuals in Saudi Arabia

Background: Toxoplasma gondii infection, known as toxoplasmosis, is a familiar worldwide zoonosis, often asymptomatic. It can affect immunocompetent and immunocompromised individuals, leading to various non-subjective manifestations, including non-inheritable and optical infections, necessitating deliberate diagnosis in special tolerant groups. The purpose of the current research was to explore the correlation between the toxoplasmosis infection and blood group phenotyping. Methods: A case-control study was conducted among adult individuals in Makkah City from September 2024 to the end of April 2025. Approximately 310 individuals participated in the study by filing the questionnaire and allowing blood samples to be collected. The ELISA technique was used to detect the IgG and IgM antibodies of T. gondii. Results: The results obtained showed that infection was associated with female compared with phallic (p 0.085). There was significance between age and infection with toxoplasmosis, particularly in the 30-39-year-old age group (54/108) 50.0% (p