Toxic Effects of Morphine on the Kidneys in Domestic Rabbits

Morphine is a drug that belongs to a group of drugs called opioid analgesics or narcotics. This study was conducted to evaluate the effect of Morphine is toxic to kidney tissue in domestic rabbits. 21 male domestic rabbits were used in this study. They were divided into three groups: the first (control) was injected with distilled water, the second and third groups, each group containing 7 rabbits, were injected with morphine subcutaneously for 35 days. The results confirmed the presence of degenerative changes represented by vascular congestion in some blood vessels, contraction of the glomerulus, and expansion of Bowman's space, in addition to the separation of some tubular cells from the basement membrane. It was an infiltration of the inside of the tubular lumen and the spread of tubular cell necrosis with the appearance of edema. The results confirmed the effect of morphine on the average diameters of the glomeruli, with significant differences.