Macrophage polarization in immune-inflammatory diseases with lung damage: The promising therapeutic strategies
Abstract
The article discusses the role of macrophage polarization in the processes of inflammation and fibrosis. Targeting the polarization of alternatively activated M2 macrophages could be a promising strategy to prevent fibrosis progression. The prospects for the treatment of immune-inflammatory diseases with lung damage, aimed at macrophage functions, are considered, including the possibilities of using the selective neuropilin 2 modulator efzophytimod in systemic sclerosis and sarcoidosis, as well as other diseases.
Fields of Study & Subjects
Immune cells in cancer
Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
Systemic Sclerosis and Related Diseases
Publication details
- Journal / source
- Rheumatology Science and Practice
- Volume
- 64
- Issue
- 1
- Pages
- 12–21
- Publication date
- 2 March 2026
- Language
- EN