Involvement of the Gasotransmitter Hydrogen Sulfide in the Effect of Ozone on the Hemoglobin Oxygen Affinity

This paper presents current data on the blood oxygen transport function and the gasotransmitters system (hydrogen sulfide and nitric oxide) and their interconnection. Hydrogen sulfide contributes to the modification of hemoglobin oxygen affinity, which is achieved through various mechanisms: the formation of sulfhemoglobin, modulation of the intraerythrocytic 2,3-DPG system, the L-arginine-NO system, and also indirectly through systemic mechanisms of hemoglobin functional properties. Based on an analysis of literature and our own data, the role of hydrogen sulfide as a gasotransmitter in the formation of blood oxygen transport function and the development of oxidative damage and hypoxic conditions is discussed.