MYO9B Gene Polymorphism (SNP rs2305767) Associated with Celiac Disease in Iraqi Patients

Introduction: The MYO9B gene is involved in maintaining the intestinal barrier and is linked with a higher risk of developing celiac disease (CD). The aim of this investigation was to link the MYO9B gene polymorphism to CD in a patient sample from Iraq. Patients and methods: In Bagdad, Iraq, 30 CD patients and 20 control individuals participated in the study. The MYO9B gene polymorphism was analyzed by gene sequencing. Enzyme-linked immunosorbent serologic assay was used to determine the concentrations of anti-transglutaminase (tTG) Ab, anti-gliadin Ab, and anti-endomysial (EMA) Ab in CD patients’ serum.Results: Three genotypes (Homozygote CC, Heterozygote CT, and Mutant Homozygote TT) and two alleles (C and T) were found for single nucleotide polymorphism (SNP) rs2305767. CD patients had three genotypes (CC, CT, and TT) for SNP, but only CC genotype was discovered in controls. The Hardy–Weinberg equilibrium analysis showed a significant difference between the patients and controls. Patients with CD had greater serum levels of gliadin, EMA, and tTG than healthy controls (P < 0.05).Conclusion: Our findings suggest that SNP rs2305767 was associated with CD.