Occupational determinacy of metabolic syndrome and its proatherogenic components in individuals with vibration disease

Introduction. Currently, the metabolic syndrome (MS) prevalence among the adult population worldwide is about 25%, or more than a billion people. Among individuals in occupations with hazardous vibrations, MS occurs in 34.6% of cases. The most common diagnostic criteria are dyslipidemia, with hypercholesterolemia recorded in 52% of patients with vibration disease (VD). However, data on the occupational risk of these disorders are lacking.Materials and Methods. A total of 241 workers in vibration-prone occupations with a diagnosis of VD was examined. All workers were assessed for the presence of MS components according to diagnostic criteria.Results. In patients with MS and VD caused by exposure to local vibration, triglyceride (TG) levels as a diagnostic component of MS are higher than in patients with VD caused by combined exposure to local and general vibration. A high degree of occupational causation of MS was established (RR=2.1 (1.6–3.1), EF=52.4%), disturbances in the concentration of high-density lipoprotein cholesterol (HDL-C) (RR=3.1 (1.3–7.6), EF=67%); and close to average degree of occupational causation – high levels of low-density lipoprotein cholesterol (LDL-C) (RR=1.4 (0.96–2.12), EF=29%).Limitations. The cross-sectional design included male subjects aged 40 to 60 years with vibration syndrome from exposure to local or combined vibration.Conclusion. A high degree of occupational risk was established for MS, as well as low HDL-C levels, and a near-moderate degree of occupational risk for high LDL-C concentrations.Compliance with ethical standards. The study was conducted in compliance with the ethical standards of the Helsinki Declaration (last revised) and Order No. 200n of Russian Federation Health Ministry the dated April 1, 2016. Conclusion of the local ethical committee of the East-Siberian Institute of Medical and Ecological Research No. 2 dated December 21, 2023. All participants gave informed voluntary written consent to participate in the study.Contribution: Kudaeva I.V. – the concept and design of the study, editing, statistical processing, writing text; Chistova N.P. – collection and processing of material, statistical processing, writing text. All authors are responsible for the integrity of all parts of the manuscript and approval of the manuscript final version.Conflict of interest. The authors declare no conflict of interest.Funding. The study had no funding and was performed within the framework of the funds allocated for exploratory scientific research of East-Siberian Institute of Medical and Ecological Research.Received: November 11, 2025 / Revised: November 14, 2025 / Accepted: December 2, 2025 / Published: January 15, 2026