Immune and genetic status in children residing in conditions of airogenic exposure to nickel

Introduction. It is quite relevant to assess effects produced on children by chemical factors (exemplified by nickel) associated with specific point single nucleotide replacements in detoxification genes.Materials and Methods. Children in the observation group (n=44) are exposed to airborne nickel amounting to 1.28 average annual MPC; children in the reference group (n=45) live in a “relatively clean” area (lower than 0.1 average daily MPC). The study relied on using mass spectrometry, enzyme-linked immune assay, allergosorbent assay, flow cytometry, and real-time PCR.Results. Inhalation exposure to nickel (up to 1.28 average daily MPC) at a dose of 0.00207 mg/kg per day resulted in a 1.73-fold increase in blood contamination in children in the observation group compared to the reference group. In the observation group, a statistically significant (p