Controlled Local Hyperthermia Device for Treatment of Proctologic (Rectal) and Cervical Cancer : Safety Evaluation in White Rats

Objective: Investigation of the mono-therapeutic effect of hyperthermia against proctological and cervical cancer. Method: For the development of the controlled local hyperthermia method, the experimental device “LEZI,” created at the Center for Bio-Nanoceramics and Nanocomposite Materials Science, Georgian Technical University, was employed. Studies were conducted on experimental animals. Results: In all experimental animals (three-month-old albino rats), tumor growth was arrested, and intratumoral necrosis developed. This method is registered with the National Intellectual Property Center of Georgia (Sakpatenti), Certificate of Deposit No. 5054: “Controlled Local Hyperthermia and Magnetic Hyperthermia for Cancer Treatment.” Conclusion: As a result, it was demonstrated and confirmed that after 7–10 treatment sessions, the tumor ulcerated, indicating positive experimental outcomes (Pathological-Anatomical Laboratory “PathGeo,” Investigation #3119-12, Histopathological Examination #15272-13, diagnosis issued on 14.01.2014, Tbilisi, Georgia). Safety: The experiment confirmed that the method is safe for animals during treatment.