A Review on Risk Factors of Febrile Neutropenia in Cancer Patients

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Authors: Febin George, Liji C. J, Agnus Therese Reji, Aparna. S, Shalini Shyam, Tebin Biju, Yadhu Krishnan Kartha
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Abstract

Febrile neutropenia (FN) often causes serious side effects in cancer patients during chemotherapy.Factors such as patient's nutritional condition, health problems, illness and the treatment approach all have an impact on how severe FN becomes.This review includes information from Indian and international studies about the occurrence, risk factors, clinical effects of FN.The reported rate of FN varies from 10% to 60%, depending on the type of cancer and the treatment given.Risk factors for FN include older age, poor general health, malnutrition, medical comorbidity, and poor performance status.FN can lead to hospitalization, halted treatment or lowered chemotherapy dosage, and all while reducing treatment effectiveness.To stop this, understanding the various contributing factors is crucial to being able to tailor relevant preventive or curative support.FN is related to higher medical costs, early death, and less adherence to chemotherapy.Granulocyte colony-stimulating factors (G-CSF) play a major role in managing and preventing FN they are generally safe but can have slight side effects.This review highlights the importance of personalized risk assessment for FN.

Fields of Study & Subjects

Neutropenia and Cancer Infections Blood disorders and treatments Antifungal resistance and susceptibility

Publication details

Journal / source
International Journal of Pharmaceutical Sciences Review and Research
Volume
86
Issue
1
Publication date
1 January 2026
Language
EN