Ishemiya va gipoksiya sharoitida hujayra metabolizmining patologik o‘zgarishlari
Abstract
Hujayra energetikasining buzilishi yurak-qon tomir va miya kasalliklarida yetakchi patogenetik omildir. Ishemiya sharoitida mitoxondrial disfunksiya, ATP sintezining tormozlanishi, anaerob glikolizning faollashuvi va oksidlovchi stress apoptoz va nekrozni qo‘zg‘atadi. Kalsiy homeostazining buzilishi patologik jarayonlarni chuqurlashtirib, qaytmas hujayra shikastlanishiga olib keladi. Ushbu mexanizmlarni tushunish samarali terapevtik strategiyalarni ishlab chiqish uchun asosdir.
Fields of Study & Subjects
Cardiac Ischemia and Reperfusion
Mitochondrial Function and Pathology
Cell death mechanisms and regulation
Publication details
- Journal / source
- Профилактическая медицина и здоровье
- Volume
- 5
- Issue
- 1
- Pages
- 160–163
- Publication date
- 20 January 2026
- Language
- UZ