Lamotrigine-Induced Stevens-Johnson Syndrome in a Young Female Patient with Atypical Anorexia Nervosa and Major Depression: A Case Report

Stevens-Johnson Syndrome (SJS) is a rare, severe cutaneous adverse reaction often triggered by medications such as lamotrigine. We present the case of a 21-year-old female with Atypical Anorexia Nervosa and Major Depression who developed SJS thirty days after initiating a psychopharmacological regimen comprising lamotrigine, fluoxetine, and olanzapine. Clinical examination revealed extensive mucocutaneous lesions, including hemorrhagic cheilitis, palpebral ulcers, and targetoid lesions. The condition resolved following immediate drug discontinuation and systemic corticosteroid treatment. This case underscores the risks of rapid titration and polypharmacy in patients with Atypical Anorexia Nervosa, where metabolic instability may alter drug metabolism. Clinicians must exercise heightened vigilance and strictly adhere to slow titration schedules in this vulnerable population.