ESTIMATING ARTERIAL AND VENOUS DYNAMICS THROUGH A VENOUS OCCLUSION PLETHYSMOGRAPHY-BASED WINDKESSEL MODEL: PRELIMINARY RESULTS

This study presents preliminary findings from a pilot investigation involving five healthy subjects to evaluate a vascular mechanics model applied to venous occlusion plethysmography. The proposed model characterizes arterial and venous mechanical properties at baseline and enables dynamic parameter estimation during post-occlusion recovery. Reactive hyperemia induced by forearm venous occlusion was assessed under baseline conditions and after physiological interventions (ibuprofen administration and exercise). The model quantified transient hemodynamic responses, consistently showing decreases in arterial and venous resistances and increases in venous compliance, followed by gradual recovery toward baseline values. Condition-dependent differences were identified: resistance reductions were more pronounced after ibuprofen administration, whereas venous compliance exhibited greater enhancement following exercise. These results demonstrate the model’s sensitivity to pharmacological and physiological modulation of vascular function. The proposed framework offers a noninvasive approach for the simultaneous assessment of arterial and venous dynamics and may contribute to opening new paths for cardiovascular function assessment.