Atypical manifestation of human herpes virus-6 encephalitis with extra-limbic lesions: a case report
Abstract
Human herpesvirus-6 (HHV-6) encephalitis represents a serious opportunistic infection in immunocompromised patients that is associated with substantial mortality and long-term neurological sequelae. The disease most often involves the limbic system, with typical neuroimaging findings restricted to the hippocampal and amygdaloid structures. Here, we describe a rare case of HHV-6 encephalitis presenting with atypical imaging features, which demonstrated near-complete resolution following ganciclovir therapy. This case underscores that HHV-6 encephalitis is not invariably confined to the limbic system and highlights the importance of prompt antiviral therapy in preventing irreversible neurological damage.
Fields of Study & Subjects
Cytomegalovirus and herpesvirus research
Viral-associated cancers and disorders
Neurological Complications and Syndromes
Publication details
- Journal / source
- encephalitis
- Publisher
- Korean Encephalitis and Neuroinflammation Society
- Volume
- 6
- Issue
- 1
- Pages
- 19–23
- Publication date
- 9 January 2026
- Language
- EN