Development and Evaluation of Gastro Rententive Tablet for Anticonvulsant Drugs

Background: The present study aimed to formulate and evaluate floating gastroretentive tablets containing Gabapentin and Nortriptyline to achieve prolonged gastric residence and sustained drug release. Methods: Floating tablets were prepared by the direct compression method using hydrophilic polymers such as HPMC K4M and Carbopol 934P along with sodium bicarbonate and citric acid as gas-generating agents. Preformulation parameters including bulk density, tapped density, compressibility index, Hausner’s ratio, and angle of repose were evaluated to determine flow properties of the powder blend. The compressed tablets were characterized for weight variation, hardness, friability, buoyancy lag time, total floating time, swelling index, and in-vitro drug release. Results: Preformulation studies demonstrated satisfactory flow properties with compressibility index values ranging from 16.00–18.33% and Hausner’s ratio between 1.19–1.22. The prepared tablets showed acceptable hardness (4.8–6.1 kg/cm²) and low friability (