Content-aware Information Compression and Selection for Whole Slide Image Analysis

Recent advances in multi-instance learning (MIL) have demonstrated impressive performance in whole slide image (WSI) analysis. However, current methods search for cues and draw conclusions from all instances or regions, resulting in excessive redundant computation and suboptimal representation quality due to irrelevant and uninformative feature interference. To address these issues, we propose CICS, an efficient and general framework that performs compact information compression and selection for high-efficiency WSI analysis. In particular, CICS features two key components: (1) context-aware compression (CAC), which partitions the instance space into sub-regions and applies learnable compression to discard irrelevant components, reduce computational complexity while facilitating information selection, and (2) global-proximity selective attention (GPSA), which cherry-picks the most informative representation with a proximity-assisted global dynamic selection strategy. Building upon these innovations, CICS forms a plug-and-play module that reduces computational complexity through compact instance representations while improving feature quality by preserving the most informative cues. Extensive experiments on six WSI classification and survival prediction datasets show that CICS consistently improves the performance of multiple representative MIL methods. It achieves 2.5%, 7.7%, and 3.9% accuracy gain over the state-of-the-art Transformer-based TransMIL, Mamba-based MambaMIL, and graph-based WIKG methods on the ESCA dataset.