Omni-fMRI: A Universal Atlas-Free fMRI Foundation Model
Abstract
Self-supervised fMRI foundation models have shown promising transfer performance, yet most rely on predefined region-level parcellations that discard fine-grained voxel information and introduce atlas-dependent biases. We propose Omni-fMRI, an atlas-free foundation model that operates directly on voxel-level signals. To enable scalable pretraining on 49,497 fMRI sessions across nine datasets, Omni-fMRI introduces a dynamic patching mechanism that substantially reduces computational cost while preserving informative spatial structure. To support reproducibility and fair comparison, we establish a comprehensive benchmark suite spanning 11 datasets and a diverse set of resting-state and task-based fMRI tasks. Experimental results demonstrate that Omni-fMRI consistently outperforms existing foundation models, providing a scalable and reproducible framework for atlas-free brain representation learning. Code and logs are available.
Fields of Study & Subjects
Functional Brain Connectivity Studies
Advanced MRI Techniques and Applications
Medical Image Segmentation Techniques
Publication details
- Journal / source
- arXiv (Cornell University)
- Publication date
- 30 January 2026
- Document type
- Preprint