Equal Marginal Power for Co-Primary Endpoints
Abstract
The choice of sample size in the context of co-primary endpoints for a randomised trial is discussed. Current guidance can leave endpoints with unequal marginal power. A method is provided to achieve equal marginal power by using the flexibility provided in multiple testing procedures. A comparison is made to several choices of rule to determine the sample size, in terms of the study design and its operating characteristics.
Fields of Study & Subjects
Statistical Methods in Clinical Trials
Statistical Methods and Bayesian Inference
Probability and Statistical Research
Publication details
- Journal / source
- arXiv (Cornell University)
- Publication date
- 20 February 2026
- Language
- EN
- Document type
- Preprint