Comparison of Atheroma Burden Changes Using Conventional vs. End-Diastolic Intravascular Ultrasound Segmentation - Post Hoc Analysis of the PACMAN-AMI Study.

Open Access CRIS of the University of Bern 2026 Open access

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Authors: Nathan Angelo Lecaros Yap, Christos V. Bourantas, Sylvain Losdat, Nicole Ng, Jonas Dominik Häner, Ibrahim Halil Tanboga, Andreas Baumbach, Tatsuhiko Otsuka, Yasushi Ueki, Anthony Mathur, Ernest Spitzer, Ryota Kakizaki
+6 more Jouke Dijkstra, Thomas Engstrøm, David Spirk, Irene Marthe Lang, Konstantinos C. Koskinas, Lorenz Räber
DOI: 10.48620/96017
Cited by: 0

Abstract

Background This study compared changes in percentage atheroma volume (PAV) using an end-diastolic (ED) intravascular ultrasound (IVUS) segmentation approach vs. the conventional 1-mm interval analysis in serial IVUS data from the PACMAN-AMI trial.Methods And Results IVUS data from the PACMAN-AMI study were analyzed by 2 core laboratories: one with 1-mm segmentation and the other with an ED-based approach. The same arterial segments were assessed at baseline and at the 52-week follow-up in patients receiving alirocumab or placebo. Changes in segment length, lumen, vessel, total atheroma volume (TAV), and PAV between baseline and follow-up were compared between methods. Biomarkers associated with atherosclerotic progression were measured and correlated with TAV and PAV changes. In all, 387 segments were analyzed. Agreement between conventional and ED volumetric analysis was excellent (intraclass coefficient >0.891, P

Fields of Study & Subjects

Coronary Interventions and Diagnostics Lipoproteins and Cardiovascular Health Cardiac Imaging and Diagnostics

Publication details

Journal / source
Open Access CRIS of the University of Bern
Publication date
24 July 2026
Language
EN