DSRT, affinity proteomics, and single-cell surface spatial proteomics in patient with acute myeloid leukemia at diagnosis

The purpose of this study was to investigate the molecular and functional mechanisms underlying resistance to FLT3 inhibitors in FLT3-mutant acute myeloid leukemia, with the goal of identifying predictive markers of response and potential combination strategies to overcome resistance. This repository contains multi-omic data generated on FLT3 mutant and wild-type AML patients. The datasets consist of selective drug sensitivity scores, soluble protein levels, and spatial proteomics data, along with annotation files linking patient IDs across datasets and drug classifications. Data processing methods and software dependencies are specified for each dataset. File List: - sDSS.csv : sDSS table with response to 528 drug perturbations in FLT3 mutant patients. - sDSS_FLT3i.csv : sDSS table with response to 8 FLT3i in FLT3 mutant and wild type patients. - olink_NPX.csv : Soluble protein data table for 17 FLT3 mutant patients. - pixelgen.RData : RData file containing a merged Seurat object with single-cell spatial proteomics data for 6 FLT3 mutant patients. - annotation.csv : Annotation file for all samples. Included is also a list of drug classes: - drug_class.csv Total size of the dataset is approximately 1.4 GB.