A PaDd-informed, Assay-calibrated Diagnostic Pathway for Suspected Pulmonary Embolism in Older Adults: From Signal to Strategy
Abstract
To the Editor: We commend Cohen et al. for introducing a prag-matic composite—Padua score × D-dimer (PaDd)—designed to refine pulmonary embolism (PE) exclusion in adults aged ≥65 years, a population often characterized by multimorbidity, physiological heterogeneity, and atypical presentations. Their single-center retrospective cohort (2021–2023) provides a compelling, hypothesis-generating signal: combining a validated venous thromboembolism risk score with D-dimer may enhance specificity without compromising safety.
Fields of Study & Subjects
Venous Thromboembolism Diagnosis and Management
Acute Myocardial Infarction Research
Cardiovascular and Diving-Related Complications
Publication details
- Journal / source
- Rambam Maimonides Medical Journal
- Volume
- 17
- Issue
- 1
- Pages
- e0009–e0009
- Publication date
- 28 January 2026
- Language
- EN