Data from: Synchronous activation of striatal cholinergic interneurons induces local serotonin release

DRYAD 2026 Dataset Open access

Read full text
Authors: Lior Matityahu, Zachary B. Hobel, Noa Berkowitz, Jeffrey M. Malgady, Naomi Gilin, Joshua L. Plotkin, Joshua A. Goldberg
DOI: 10.5061/dryad.2z34tmq18
Cited by: 0

Abstract

Striatal cholinergic interneurons (CINs) activate nicotinic acetylcholine receptors on dopamine axons to extend the range of dopamine release. Here we show that synchronous activation of CINs induces and extends the range of local serotonin release via a similar mechanism. This process is exaggerated in the hypercholinergic striatum of a mouse model of OCD-like behavior, implicating CINs as critical regulators of serotonin levels in the healthy and pathological striatum.

Fields of Study & Subjects

Neuroscience and Neuropharmacology Research Neurotransmitter Receptor Influence on Behavior Nicotinic Acetylcholine Receptors Study

Publication details

Journal / source
DRYAD
Publication date
25 February 2026
Language
EN
Document type
Dataset