Adherence and Engagement in Videoconference Interventions for Treatment-resistant Depression

Background: Adherence and engagement in videoconference therapy are key challenges in the management of treatment-resistant depression (TRD). This study examines adherence and engagement in two videoconference interventions, a lifestyle modification program (LMP) and mindfulness-based cognitive therapy (MBCT) in individuals with TRD, exploring predictors of engagement and associations with treatment outcomes. Method: A secondary analysis was conducted using data from a randomized controlled trial (n = 63) comparing LMP and MCBT. Sociodemographic and clinical predictors of engagement were analysed via ordinal logistic regression. Results: Adherence was higher in the LMP group (47.1%) than in the MBCT group (20.7%). Older age predicted greater engagement (p .020). A trend toward significance was observed between engagement and depression remission (p = .0683). Conclusions: These findings highlight the importance of tailoring those interventions to improve intervention efficacy and improve adherence engagement, but more research is needed to confirm these results.