Formulation and Evaluation of Taste Masked Oral Disintegrating Films of Tolterodine Tartarate

Tolterodine tartarate is a widely used antimuscarinic agent that is used in the treatment of urinary incontinence. This study includes the formulation and evaluation of Oral Disintegrating Films of Tolterodine tartarate, which helps in obtaining the better dissolution rate, quick onset of action and improving the patient compliance. Tolterodine ODF were prepared by solvent casting method using water soluble polymers like HPMC E15, HPMC 5cps and HPMC 50cps in different ratios. These prepared films were evaluated for in-vitro disintegration time, film thickness, drug content, in-vitro drug release etc. Based on the results, the formulation containing HPMC E15 in 1:5 ratio was found to be as the best formulation. The in-vitro disintegration time was 20.02+0.32 sec and a drug release was found to be 99.61+ 0.23 % in 15 minutes.