Non-Invasive Follicular Thyroid Neoplasm with Papillary-Like Nuclear Features: Emphasizing Diagnostic Reclassification

Non-invasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) is a recently recognized thyroid tumour entity with indolent behaviour and extremely low malignant potential, introduced to avoid overdiagnosis and overtreatment of encapsulated follicular variants of papillary thyroid carcinoma (PTC). ¹,² We report a case of an adult male presenting with a solitary thyroid nodule clinically and radiologically suspicious for malignancy. Fine-needle aspiration cytology suggested atypia of undetermined significance – Bethesda category III, whereas USG neck was suggestive of TIRADS 5, prompting surgical intervention. Final histopathological examination revealed the diagnosis of NIFTP. This case highlights the diagnostic difficulty of NIFTP on preoperative fine-needle aspiration cytology and emphasizes the importance of strict histopathological criteria for accurate diagnosis and appropriate treatment.