Squamous Cell Carcinoma of the Prostate: A Case Report and Brief Literature Review

Squamous cell carcinoma (SCC) of the prostate is a rare and aggressive variant, accounting for only 0.5–1% of all prostate malignancies, and is associated with a poor prognosis. We present the case of an 80-year-old male who presented to the Urology Clinic in Harare, Zimbabwe, with symptoms of bladder outlet obstruction. A transurethral resection of the prostate (TURP) was performed. Histopathological examination revealed a malignant neoplasm with squamous differentiation, which was confirmed by immunohistochemistry to be consistent with pure SCC. This case highlights the importance of histopathological and immunohistochemical evaluation in diagnosing this rare entity, particularly in patients presenting with obstructive symptoms and a non-elevated prostate-specific antigen (PSA) level.