A Eficácia dos Probióticos na Atenuação dos Sintomas em Pacientes Infectados Com SARS-CoV-2: Uma Revisão Integrativa

This study presents an integrative review on the influence of gut microbiota on SARS-CoV-2 infection. The gut microbiota, comprising trillions of microorganisms, plays a crucial role in human health, including modulating immune responses and maintaining intestinal homeostasis. Changes in the microbiota, known as dysbiosis, can negatively impact health by increasing susceptibility to various diseases, including viral infections like COVID-19. Evidence demonstrates that SARS-CoV-2 infection can significantly alter the composition of the gut microbiota, resulting in gastrointestinal symptoms and potentially exacerbating the clinical course of the disease. This work reviewed clinical and pre-clinical studies investigating the relationship between gut dysbiosis and the severity of COVID-19, highlighting therapeutic interventions such as the use of probiotics, prebiotics, and fecal microbiota transplantation. The results indicate that modulating the gut microbiota may be a promising strategy to improve clinical outcomes and reduce symptom severity in COVID-19 patients. However, further studies are necessary to validate the efficacy and safety of these therapeutic approaches.