The Comparison of Colon Anastomosis Patency of Hand-Sewn Technique with Application of 2-Octyl-Cyanoacrylate Tissue Adhesive in Wistar Rats

Background: Intestinal anastomosis is often performed, especially in cases of infection or trauma. Generally, intestinal anastomosis can be performed using the hand-sewn technique or primary suture using absorbable or non-absorbable sutures. However, there is also another technique that uses 2-octyl-cyanoacrylate tissue adhesive to bind the two edges of the wound together and allow normal healing to occur. Both techniques have their advantages and disadvantages. Objective: This study aims to analyze the effectiveness of hand-sewn suturing techniques and the application of 2-octyl-cyanoacrylate tissue adhesive in Wistar rats. Methods: This study is an experimental analytical study with a randomized post-test only group design. This study involved 20 samples, each divided into 2 groups of 10 samples (50%). On day 0, colon anastomosis in both groups will be assessed using a syringe test to determine anastomotic patency. Observations will be made from day 0 to day 5 after anastomosis. In experimental animals that died before day 5, re-laparotomy was performed and anastomosis patency was examined using the syringe test. If the experimental animals survived until day 5, re-laparotomy was performed and anastomosis patency was re-examined using the syringe test on day 5. Results: The RR analysis showed a figure of 0.643 with a 95% confidence interval from 0.101 to 4.097, and a p-value of 0.64, indicating no statistically significant difference between the two groups. Conclusion: There was no significant difference in anastomotic patency risk between the hand-sewn suture group and the group using 2-octyl cyanoacrylate tissue adhesive in Wistar rats.