Formulation, Characterization and In-Vitro Evaluation of Curcumin Loaded Liposome for Colon Drug delivery

International Journal of Research and Innovation in Applied Science 2026 Open access

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Authors: Manish Tripathi, Ajay Singh Thakur, Prachi Tripathi, Vaibhav Rajoriya, R.K. Parashar, Yogesh Sharma, Deepak Koshti
DOI: 10.51584/ijrias.2025.10120077
Cited by: 0

Abstract

Curcumin (CUR) exhibits potent anticancer activity but suffers from poor bioavailability and limited colonspecific delivery. The present study reports the development and characterization of unconjugated liposomes (UL) and hyaluronic acid (HA)-conjugated liposomes (HTL) for colon-targeted delivery of CUR. Liposomes were prepared using the thin-film hydration method and conjugated with HA via carbodiimide-mediated coupling. Physicochemical characterization revealed spherical vesicles with mean diameters of 112.1 ± 1.8 nm (UL) and 132.4 ± 3.4 nm (HTL), low polydispersity indices (

Fields of Study & Subjects

Nanoparticle-Based Drug Delivery Curcumin's Biomedical Applications Advanced Drug Delivery Systems

Publication details

Journal / source
International Journal of Research and Innovation in Applied Science
Volume
X
Issue
XII
Pages
917–927
Publication date
1 January 2026