THE ROLE OF CALCITONIN GENE-RELATED PEPTIDE AND PENTRAXIN-3 IN MIGRAINE PATHOPHYSIOLOGY AND DIAGNOSIS

Background: Migraine is a prevalent neurological disorder characterized by neurovascular dysregulation and inflammation. Biomarkers such as calcitonin gene-related peptide (CGRP) and pentraxin-3 (PTX3) may play a key role in migraine pathophysiology. Objective: To evaluate serum CGRP and PTX3 levels in migraine patients compared with healthy controls and explore their clinical associations. Methods: A cross-sectional study was conducted including migraine patients (n=40) and age-matched controls (n=40). Demographic, clinical, and triggering factors were recorded. Hematological parameters, CGRP, and PTX3 levels were analyzed. Data were assessed using Mann-Whitney U and t-tests with significance set at p