Tolerability of lopinavir versus dolutegravir in children and adolescents with HIV (LoDoCA): a prospective cohort study in lesotho, Southern Africa

Zurich Open Repository and Archive (University of Zurich) 2026 Open access

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Authors: Jacob Blankenberger, Akash Devendra, Meenakshi Bakaya, Tristan Taylor Lee, Teresa L. F. Steffy, Thithili Makhesi, Charlie J. Gilbride, Jennifer M. Belus, Lineo Thahane, Nadine Tschumi, Nthuseng Bridgett Marake, Tapiwa Tarumbiswa
+4 more Reto Huber, Frédérique Chammartin, Niklaus Daniel Labhardt, Jennifer A Brown
DOI: 10.5167/uzh-284366
Cited by: 0

Abstract

Background: Children and adolescents with HIV previously taking ritonavir-boosted lopinavir (LPV/r)-based antiretroviral therapy (ART) were recently programmatically transitioned to dolutegravir (DTG)-based ART in Lesotho, southern Africa. We investigated associated changes in treatment satisfaction and potential side effects. Methods: This single-center prospective cohort study enrolled participants

Fields of Study & Subjects

HIV/AIDS drug development and treatment HIV/AIDS Research and Interventions HIV-related health complications and treatments

Publication details

Journal / source
Zurich Open Repository and Archive (University of Zurich)
Publication date
2 February 2026
Language
EN